| Primary Identifier | MGI:1354161 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 50721 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including NAD+-protein-arginine ADP-ribosyltransferase activity; TORC2 complex binding activity; and histone deacetylase activity, NAD-dependent. Involved in several processes, including chromatin remodeling; regulation of nucleobase-containing compound metabolic process; and regulation of protein localization. Located in nucleus. Is active in chromatin. Is expressed in several structures, including alimentary system; central nervous system; gonad; musculature; and retina. Used to study progeria. Orthologous to human SIRT6 (sirtuin 6). PHENOTYPE: Mice homozygous for a null allele display late postnatal lethality with lordokyphosis, progressive lymphopenia, loss of subcutaneous fat, reduced bone density, decreased serum glucose, increased chromosomal instability, and increased sensitivity to ionizing radiation. Some KO alleles cause retinal and corneal degeneration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
