Primary Identifier | MGI:1921488 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 74238 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA binding activity. Predicted to be involved in termination of mitochondrial transcription. Located in mitochondrial nucleoid. Orthologous to human MTERF2 (mitochondrial transcription termination factor 2). PHENOTYPE: Mice homozygous for a gene-trapped allele gain less weight than wild-type controls, develop a myopathy, and show memory deficits, decreased levels of mitochondrial transcripts, an imbalanced tRNA pool, impaired oxidative phosphorylation, reduced respiratory function, and enlarged mitochondrial mass. [provided by MGI curators] |