| Primary Identifier | MGI:1270841 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 12952 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables E-box binding activity; enzyme binding activity; and nuclear receptor binding activity. Involved in several processes, including circadian regulation of gene expression; negative regulation of cell communication; and regulation of primary metabolic process. Acts upstream of or within circadian rhythm. Located in mitochondrion and nucleus. Is expressed in several structures, including early conceptus; female reproductive system; and liver. Human ortholog(s) of this gene implicated in delayed sleep phase syndrome. Orthologous to human CRY1 (cryptochrome circadian regulator 1). PHENOTYPE: Mice homozygous for targeted knock-out mutations exhibit a shortened circadian behavior period under constant darkness. Male mice homozygous for an endonuclease-mediated null allele display oligozoospermia and increased male germ cell apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
