Primary Identifier | MGI:2444738 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 237465 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ubiquitin-modified histone reader activity. Involved in acrosome assembly and sperm flagellum assembly. Located in several cellular components, including manchette; sperm flagellum; and sperm head. Orthologous to human CCDC38 (coiled-coil domain containing 38). PHENOTYPE: Mice homozygous for a knockout allele exhibit male sterility associated with oligospermia and asthenospermia, impaired spermiogenesis, elongated and ectopic manchettes, and teratospermia with multiple morphological abnormalities of the sperm flagella. [provided by MGI curators] |