| Primary Identifier | MGI:2149961 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 114774 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable actin binding activity; enzyme binding activity; and leucine zipper domain binding activity. Involved in several processes, including positive regulation of cellular senescence; positive regulation of hydrogen peroxide-mediated programmed cell death; and regulation of gene expression. Acts upstream of or within several processes, including negative regulation of T cell receptor signaling pathway; negative regulation of lymphocyte proliferation; and positive regulation of amyloid precursor protein biosynthetic process. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and respiratory system. Orthologous to human PAWR (pro-apoptotic WT1 regulator). PHENOTYPE: Mice homozygous for disruptions in this gene show lower levels of apoptosis and increased proliferation of both T cells and B cells. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
