Primary Identifier | MGI:1096880 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 21664 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable phosphatidylinositol phosphate binding activity. Acts upstream of or within FasL biosynthetic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; limb segment; respiratory system; and sensory organ. Orthologous to human PHLDA1 (pleckstrin homology like domain family A member 1). PHENOTYPE: Mice homozygous for a targeted null mutation are viable, fertile and morphologically normal. Relative to wild-type littermates, homozygous null mice display no obvious defects in immune function, Fas expression or T-cell apoptosis. [provided by MGI curators] |