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Protein Coding Gene : Mettl1 methyltransferase 1, tRNA methylguanosine
Primary Identifier  MGI:1339986 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  17299
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable internal mRNA (guanine-N7-)-methyltransferase activity and tRNA (guanine(46)-N7)-methyltransferase activity. Predicted to be involved in tRNA (guanine-N7)-methylation and tRNA stabilization. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of tRNA (m7G46) methyltransferase complex. Orthologous to human METTL1 (methyltransferase 1, tRNA methylguanosine).
PHENOTYPE: Mice with lost of expression in limb bud mesenchyme display short limbs, reduced body size, impaired endochondral bone formation, and decreased bone mass. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 2810012D02 gene,
  • 2810012D02Rik,
  • Mettl1,
  • MGI:1917465,
  • methyltransferase 1, tRNA methylguanosine
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