| Primary Identifier | MGI:2143539 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 216456 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable glutaminase activity. Predicted to be involved in glutamate biosynthetic process and glutamine catabolic process. Predicted to act upstream of or within reactive oxygen species metabolic process and regulation of apoptotic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; limb; nervous system; skeleton; and urinary system. Orthologous to human GLS2 (glutaminase 2). PHENOTYPE: Homozygous mice for a null allele exhibit increased fasting plasma glucagon and glutamine levels with lower fasting blood glucose levels, decreased hepatic glucose production in response to glucagon or lactate and glutamine and pancreatic alpha cell hyperplasia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
