| Primary Identifier | MGI:2444945 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 237625 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calcium-dependent phospholipase A2 activity. Involved in several processes, including positive regulation of histamine secretion by mast cell; positive regulation of mast cell differentiation; and positive regulation of prostaglandin biosynthetic process. Acts upstream of or within several processes, including negative regulation of amyloid-beta clearance; regulation of gene expression; and spermatid development. Predicted to be located in centriole and recycling endosome. Is expressed in several structures, including alimentary system; cranium; genitourinary system; integumental system; and nervous system. Orthologous to human PLA2G3 (phospholipase A2 group III). PHENOTYPE: Homozygous mice have reduced male fertility with smaller litter size and decreased susceptibility to IgE antigen-induced passive systemic and cutaneous anaphylaxis due to impaired mast cell maturation, degranulation and histamine release. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
