| Primary Identifier | MGI:2158663 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 170835 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity. Acts upstream of or within negative regulation of neuron projection development and negative regulation of peptidyl-serine phosphorylation. Located in dendritic shaft; growth cone; and plasma membrane. Is expressed in alimentary system; ear; nervous system; respiratory system; and skeleton. Orthologous to human INPP5J (inositol polyphosphate-5-phosphatase J). PHENOTYPE: Mice homozygous for a null allele are viable, fertile, and show normal mammary gland development and no spontaneous mammary tumors. However, in an oncogene-driven breast cancer mouse model, mice show increased mammary hyperplasia and tumor growth paradoxically associated with reduced lung metastases. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
