Primary Identifier | MGI:1097163 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 18972 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA binding activity. Involved in DNA biosynthetic process. Part of delta DNA polymerase complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and hemolymphoid system. Orthologous to human POLD2 (DNA polymerase delta 2, accessory subunit). PHENOTYPE: Mice homozygous for a knock-out allele show complete embryonic lethality before implantation, an increased number of empty decidua, and failure of blastocysts to hatch from the zona pellucida with increased cell death during outgrowth culture. [provided by MGI curators] |