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Protein Coding Gene : Ppia peptidylprolyl isomerase A
Primary Identifier  MGI:97749 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  268373
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables integrin binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in platelet aggregation. Acts upstream of or within neuron differentiation. Located in extracellular space. Is expressed in several structures, including early conceptus; gonad; hemolymphoid system gland; liver; and skeletal muscle. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to human PPIA (peptidylprolyl isomerase A).
PHENOTYPE: Mice homozygous for disruptions in this gene tend to develop blepharitis (about 30% of mice) as well as inflammation in other organs. Some background dependent embryonic lethality occurs but adults are robust and live normal life spans. [provided by MGI curators]
  • synonyms:
  • CypA,
  • cyclophilin A,
  • peptidylprolyl isomerase A,
  • Cphn,
  • cyclophilin,
  • Ppia,
  • MGD-MRK-2108,
  • CyP-18,
  • MGD-MRK-13591
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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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Canonical gene --> Transcripts in specific strains.

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6 Pathways

Trail: ProteinCodingGene

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Expression

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Phenotype

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Disease

Mouse features --> Human diseases

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