| Primary Identifier | MGI:96016 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 110257 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable G protein-coupled receptor binding activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Acts upstream of or within erythrocyte development; in utero embryonic development; and response to bacterium. Predicted to be located in extracellular space. Predicted to be part of haptoglobin-hemoglobin complex and hemoglobin complex. Is expressed in bone marrow; liver; visceral pericardium; and yolk sac. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Orthologous to human HBA1 (hemoglobin subunit alpha 1) and HBA2 (hemoglobin subunit alpha 2). PHENOTYPE: Homozygotes for a targeted deletion of both adult hemoglobin-alpha genes die in late gestation with symptoms resembling human hydrops fetalis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
