| Primary Identifier | MGI:2159680 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 171283 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables phosphatidylserine binding activity. Acts upstream of or within positive regulation of mast cell activation; response to lipopolysaccharide; and response to wounding. Located in brush border and cell surface. Is expressed in aorta-gonad-mesonephros; brain; genitourinary system; liver; and lung. Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal response to S. mansoni egg challenge. Mice homozygous for an allele lacking the mucin domain display impaired regulatory B cell function and systemic autoimmunity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
