Primary Identifier | MGI:2445125 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 276891 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables phosphatidylserine binding activity. Acts upstream of or within apoptotic cell clearance. Predicted to be located in membrane. Is expressed in aorta-gonad-mesonephros; brain; gonad; liver; and lung. Used to study systemic lupus erythematosus. Orthologous to human TIMD4 (T cell immunoglobulin and mucin domain containing 4). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired macrophage phagocytosis, altered macrophage physiology, and increased peritoneal lymphoid and meyloid cell numbers. [provided by MGI curators] |