| Primary Identifier | MGI:95561 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 14257 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables vascular endothelial growth factor receptor activity. Involved in lymphangiogenesis; regulation of blood vessel remodeling; and sprouting angiogenesis. Acts upstream of or within lung alveolus development; positive regulation of cell population proliferation; and respiratory system process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Used to study hereditary lymphedema. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4). PHENOTYPE: Embryos homozygous for a targeted null mutation show growth retardation, vascular abnormalities, severe anemia and die from cardiovascular failure at embryonic day 9.5. Heterozygotes for another mutation show abdominal chylous ascites, abnormal lymphaticvessels, and lymphedema. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
