| Primary Identifier | MGI:102944 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 22210 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Involved in positive regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including chromosome organization; positive regulation of reciprocal meiotic recombination; and sperm axoneme assembly. Located in XY body and chromatin. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human UBE2B (ubiquitin conjugating enzyme E2 B). PHENOTYPE: Homozygous null mice exhibit male sterility associated with a defect in the elongation and nuclear condensation stage of spermiogenesis. Sperm flagellum abnormalities characterized by abnormal distribution of periaxonemal structures are observed in addition to sperm head shape anomalies. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
