| Primary Identifier | MGI:106919 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 22333 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables oxysterol binding activity and voltage-gated monoatomic anion channel activity. Involved in negative regulation of reactive oxygen species metabolic process and regulation of mitophagy. Acts upstream of or within behavioral fear response; learning; and neuron-neuron synaptic transmission. Located in membrane and mitochondrion. Is expressed in several structures, including central nervous system; cortical renal tubule; eye; hemolymphoid system gland; and testis. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human VDAC1 (voltage dependent anion channel 1). PHENOTYPE: Homozygous null mutants exhibit approximately 60% embryonic mortality, with loss occurring at embryonic day 10.5-11.5. Survivors exhibit defective cued fear conditioning and spatial learning. Heterozygotes also exhibit about 12% prenatal mortality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
