| Primary Identifier | MGI:107729 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 16145 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables GTPase activity. Involved in several processes, including defense response to other organism; negative regulation of PERK-mediated unfolded protein response; and positive regulation of autophagosome maturation. Acts upstream of or within cellular response to interferon-beta. Located in cytosol. Is active in endoplasmic reticulum. Is expressed in alimentary system; hemolymphoid system; liver; thymus primordium; and tongue. Human ortholog(s) of this gene implicated in inflammatory bowel disease 19 and tuberculosis. Orthologous to human IRGM (immunity related GTPase M). PHENOTYPE: Mice homozygous for a null allele exhibit impaired cell-autonomous Toxoplasma killing. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
