Primary Identifier | MGI:2144489 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 268420 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables mRNA N6-methyladenosine dioxygenase activity. Involved in mRNA destabilization and spermatogenesis. Located in nuclear speck. Is expressed in brain; intestine; and liver. Orthologous to human ALKBH5 (alkB homolog 5, RNA demethylase). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced male fertility associated with oligo- and teratozoopermia and male germ cell apoptosis. [provided by MGI curators] |