| Primary Identifier | MGI:1890496 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 68626 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable 3'-tRNA processing endoribonuclease activity and tRNA-specific ribonuclease activity. Predicted to be involved in mitochondrial tRNA 3'-end processing. Located in mitochondrial nucleoid. Is expressed in extraembryonic component and placenta. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 17. Orthologous to human ELAC2 (elaC ribonuclease Z 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete embryonic lethality. Homozygosity for the p.A537T mutation or a prostate-specific KO leads to prostate hyperplasia and to exacerbated prostate cancer incidence in a prostate-cancer-sensitive background. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
