| Primary Identifier | MGI:107731 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 327954 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in cilium movement. Located in motile cilium. Part of axonemal dynein complex. Is expressed in central nervous system. Human ortholog(s) of this gene implicated in spermatogenic failure 45. Orthologous to human DNAH2 (dynein axonemal heavy chain 2). PHENOTYPE: Mice homozygous for a null allele show male sterility with immotile sperm, multiple sperm flagellar morphological abnormalities, impaired flagella elongation and head shaping during spermiogenesis, and dysregulated developmental expression and localization of basal body and annulus components. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
