| Primary Identifier | MGI:95303 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 13681 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable double-stranded RNA binding activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation and positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear stress granule; perinuclear region of cytoplasm; and plasma membrane. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in several structures, including central nervous system; liver; lung; ovary; and sensory organ. Orthologous to human EIF4A1 (eukaryotic translation initiation factor 4A1). PHENOTYPE: Mice with loss of expression in developing B cells display near complete absence of splenic B cells. Loss of expression in mature B cells results in impaired development after activation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
