Primary Identifier | MGI:3029307 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 237858 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in endosome to plasma membrane protein transport and glucose import in response to insulin stimulus. Acts upstream of or within establishment of localization in cell and vesicle fusion to plasma membrane. Located in cytoplasmic vesicle membrane; perinuclear region of cytoplasm; and plasma membrane. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; nervous system; sensory organ; and white fat. Orthologous to human TRARG1 (trafficking regulator of GLUT4 (SLC2A4) 1 (gene/pseudogene)). PHENOTYPE: Mice homozygous for a knock-out allele display abnormal adipocyte glucose uptake and show increased body weight, elevated blood insulin and glucose levels, and insulin resistance when fed a high-fat diet. [provided by MGI curators] |