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Protein Coding Gene : Nle1 notchless homolog 1
Primary Identifier  MGI:2429770 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  217011
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Acts upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and positive regulation of canonical Wnt signaling pathway. Located in nucleolus. Is expressed in several structures, including 2-cell stage embryo; gonad; hemolymphoid system gland; inner cell mass; and liver. Orthologous to human NLE1 (notchless homolog 1).
PHENOTYPE: Homozygous null mice display embryonic lethality before somite formation, most blastocysts fail to hatch out of the zona pellucida, and apoptosis is increased in the inner cell mass. [provided by MGI curators]
  • synonyms:
  • lethal, Chr 11, Justice 4,
  • MGI:2385862,
  • l11Jus4,
  • AL022765,
  • MGC:25690,
  • lethal, Chr 11, Justice 1,
  • Nle,
  • notchless homolog 1,
  • Nle1,
  • MGI:2671268,
  • cDNA sequence BC018399,
  • expressed sequence AL022765,
  • MGI:2144343,
  • notchless,
  • BC018399,
  • MGI:2671264,
  • l11Jus1
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2 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

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Genes --> Homologs

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Disease

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