| Primary Identifier | MGI:1313258 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 20556 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables tRNA binding activity. Involved in T cell mediated immunity; T cell proliferation involved in immune response; and tRNA stabilization. Acts upstream of or within negative regulation of cell population proliferation and response to bacterium. Is active in cytoplasm. Is expressed in temporal bone. Orthologous to human SLFN12 (schlafen family member 12) and SLFN12L (schlafen family member 12 like). PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit increased susceptibility to bacterial and viral infections, reduced T cell numbers, decreased T cell proliferation, and increased apoptosis of activated T cells. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
