| Primary Identifier | MGI:1313259 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 20555 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA nuclease activity and ribosome binding activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of T cell proliferation; and negative regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including gut; male reproductive gland or organ; nervous system; oviduct; and spleen. Orthologous to human SLFN12 (schlafen family member 12) and SLFN12L (schlafen family member 12 like). PHENOTYPE: Mice homozygous for a null allele show normal thymus cellularity and expression of cell surface markers on thymocytes and peripheral lymphocytes. Mice homozygous for a different null allele show normal immune cell populations and MOG-induced experimental autoimmune encephalitis development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
