| Primary Identifier | MGI:3652048 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 237891 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables G-protein alpha-subunit binding activity. Involved in positive regulation of G protein-coupled receptor signaling pathway and regulation of cilium beat frequency involved in ciliary motility. Colocalizes with ciliary basal body and plasma membrane. Used to study primary ciliary dyskinesia. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 41. Orthologous to human GAS2L2 (growth arrest specific 2 like 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit hydrocephaly, dextrocardia, situs ambiguus, abnormal tracheal ciliated epithelium morphology, impaired mucociliary clearance, and partial neonatal lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
