| Primary Identifier | MGI:1929608 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 56321 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable leucine zipper domain binding activity; protein kinase binding activity; and tau protein binding activity. Acts upstream of or within several processes, including negative regulation of amyloid precursor protein biosynthetic process; negative regulation of apoptotic signaling pathway; and regulation of mitotic cell cycle. Located in cytoplasm and nucleolus. Part of transcription regulator complex. Is expressed in several structures, including early conceptus; genitourinary system; liver; nervous system; and tooth. Orthologous to human AATF (apoptosis antagonizing transcription factor). PHENOTYPE: Homozygous embryos do not develop past the compacted morula stage, and after failing to maintain compaction. Mutant embryos show abnormal morphology at E3.5, with most not forming a blastocoel cavity. Severely reduced cell proliferation is observed before blastocyst formation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
