Primary Identifier | MGI:107416 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 20922 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA polymerase II complex binding activity and protein heterodimerization activity. Acts upstream of or within negative regulation of transcription elongation by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of DSIF complex. Is expressed in several structures, including cerebral cortex; genitourinary system; liver; lung; and spleen. Orthologous to human SUPT4H1 (SPT4 homolog, DSIF elongation factor subunit). PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality at E7.5. Mice heterozygous for a knock-out allele partially suppress the motor defects and premature death associated with Tg(HDexon1)62Gpb. [provided by MGI curators] |