Primary Identifier | MGI:1096866 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 12643 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within bone development and negative regulation of bone trabecula formation. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including cartilage; sensory organ; skeleton; trachea cartilaginous ring; and ventral body wall. Orthologous to human CHAD (chondroadherin). PHENOTYPE: Mice homozygous for a knock-out allele exhibit widened epiphyseal growth plate, abnormal tracbecular and cortical bone morphology and lower femoral neck failure load and tibial strength. [provided by MGI curators] |