Primary Identifier | MGI:96696 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 107656 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable structural molecule activity. Involved in spermatogenesis. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in keratin filament. Is expressed in several structures, including alimentary system; gonad; hemolymphoid system gland; metanephros; and respiratory system. Human ortholog(s) of this gene implicated in epidermolytic palmoplantar keratoderma 1. Orthologous to human KRT9 (keratin 9). PHENOTYPE: Mice homozygous for a knock-out allele exhibit hyperpigmented calluses on the footpad with acanthosis, hyperkeratosis, thick epidermis and increased keratinocyte proliferation. [provided by MGI curators] |