| Primary Identifier | MGI:1202306 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 15171 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable neuropeptide hormone activity; type 1 orexin receptor binding activity; and type 2 orexin receptor binding activity. Involved in positive regulation of cold-induced thermogenesis. Located in perinuclear region of cytoplasm. Is expressed in several structures, including integumental system; nervous system; reproductive system; retina; and skeleton. Used to study narcolepsy. Human ortholog(s) of this gene implicated in heroin dependence and narcolepsy. Orthologous to human HCRT (hypocretin neuropeptide precursor). PHENOTYPE: Homozygotes for a targeted null mutation exhibit altered sleep patterns, frequent periods of behavioral arrest resembling human narcolepsy, and attenuated morphine dependence. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
