| Primary Identifier | MGI:1922056 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 217203 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in several processes, including glycoprotein biosynthetic process; positive regulation of intracellular signal transduction; and positive regulation of macromolecule biosynthetic process. Located in plasma membrane. Orthologous to human TMEM106A (transmembrane protein 106A). PHENOTYPE: Mice homozygous for a knock-out allele show increased sensitivity to lipopolysaccharide (LPS)-induced septic shock and cecal ligation puncture treatment, along with enhanced M1-type polarization of macrophages and increased LPS-induced inflammation via the MAPK and NF-kappaB signaling pathways. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
