Primary Identifier | MGI:1306823 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 217207 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable RNA binding activity; RNA helicase activity; and identical protein binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol and nuclear body. Predicted to be part of U2-type catalytic step 2 spliceosome. Orthologous to human DHX8 (DEAH-box helicase 8). PHENOTYPE: Mice homozygous for a knock-out allele show peri-implantation lethality. In vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths with a poorly defined inner cell mass after 3 days in culture. [provided by MGI curators] |