| Primary Identifier | MGI:1921749 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 74499 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including BMP binding activity; DNA-binding transcription factor binding activity; and carbohydrate binding activity. Acts upstream of or within negative regulation of ossification; negative regulation of signal transduction; and ossification. Predicted to be located in Golgi apparatus. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space. Is expressed in several structures, including arterial system; jaw; limb bud; nervous system; and skeleton. Used to study SOST-related sclerosing bone dysplasia and sclerosteosis 1. Human ortholog(s) of this gene implicated in autosomal dominant craniodiaphyseal dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin). PHENOTYPE: Mice homozygous for a null allele exhibit an increase in trabecular and cortical bone volume, mineral density, and formation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
