| Primary Identifier | MGI:1913563 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 66313 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including SMAD binding activity; identical protein binding activity; and transforming growth factor beta receptor binding activity. Predicted to be involved in negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; positive regulation of trophoblast cell migration; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in nuclear speck. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including cardiovascular system; eye; genitourinary system; gut; and lung. Used to study diffuse large B-cell lymphoma. Orthologous to human SMURF2 (SMAD specific E3 ubiquitin protein ligase 2). PHENOTYPE: Mice homozygous for a knock-out allele occasionally exhibit kinked or looped tails and abnormal vertebrae. Mice homozygous or heterozygous for a gene trap allele exhibit increased tumor incidence and delayed cellular senescence. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
