Primary Identifier | MGI:2158813 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 170930 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables SUMO transferase activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II and protein sumoylation. Is active in several cellular components, including hippocampal mossy fiber to CA3 synapse; postsynaptic cytosol; and presynaptic cytosol. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; eye; and heart. Orthologous to human SUMO2 (small ubiquitin like modifier 2). PHENOTYPE: Mice homozygous for a null allele display severe embryonic growth retardation and die at approximately embryonic day E10.5. [provided by MGI curators] |