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Protein Coding Gene : Socs3 suppressor of cytokine signaling 3
Primary Identifier  MGI:1201791 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  12702
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables miRNA binding activity and phosphotyrosine residue binding activity. Involved in cellular response to interleukin-17. Acts upstream of or within several processes, including branching involved in labyrinthine layer morphogenesis; cellular response to leukemia inhibitory factor; and negative regulation of insulin receptor signaling pathway. Predicted to be located in cytosol. Predicted to be active in cytoplasmic side of plasma membrane. Is expressed in several structures, including extraembryonic component; liver; placenta; retina; and spleen. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SOCS3 (suppressor of cytokine signaling 3).
PHENOTYPE: Mice homozygous for mutations cause impairment if gene expression show immunological and hematopoetic abnormalities. Complete gene disruption causes lethality. [provided by MGI curators]
  • synonyms:
  • Socs3,
  • SOCS-3,
  • E2a-Pbx1 target gene in fibroblasts 10,
  • CIS3,
  • cytokine inducible SH2-containing protein 3,
  • cytokine-inducible SH2 protein 3,
  • suppressor of cytokine signaling 3,
  • STAT-induced STAT inhibitor 3,
  • EF-10,
  • Cish3,
  • SSI-3
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Features --> Cross References

Genome

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1 Transgenic Expressors

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

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Interactions

21 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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