Primary Identifier | MGI:96911 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 17134 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of gene expression and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including adult behavior; in utero embryonic development; and regulation of epidermal cell differentiation. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MAFG (MAF bZIP transcription factor G). PHENOTYPE: Mice homozygous for disruptions in this gene exhibit a background sensitive increase in perinatal lethality, hemopoietic abnormalities, and locomotor difficulties. [provided by MGI curators] |