| Primary Identifier | MGI:1924833 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 77583 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables lipase activity; palmitoleyl hydrolase activity; and protein-containing complex destabilizing activity. Involved in negative regulation of Wnt signaling pathway. Acts upstream of or within bone development; negative regulation of canonical Wnt signaling pathway; and regulation of bone mineralization. Predicted to be located in extracellular region. Is expressed in several structures, including foregut; genitourinary system; primitive streak; respiratory system; and sensory organ. Orthologous to human NOTUM (notum, palmitoleoyl-protein carboxylesterase). PHENOTYPE: Mice homozygous for a null mutation display perinatal lethality, abnormal kidney development, and impaired tracheal cartilage development. Mice homozygous for a gene trapped allele exhibit abnormal dentin development, periodontal inflammation, tooth decay and increased bone mineral density. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
