| Primary Identifier | MGI:1261827 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 13435 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables S-adenosylmethionine-dependent methyltransferase activity and nucleic acid binding activity. Involved in autosome genomic imprinting; negative regulation of gene expression via chromosomal CpG island methylation; and transposable element silencing by piRNA-mediated DNA methylation. Acts upstream of or within several processes, including cellular response to amino acid stimulus; cellular response to bisphenol A; and epigenetic regulation of gene expression. Located in chromosome; cytoplasm; and nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; limb mesenchyme; and sensory organ. Human ortholog(s) of this gene implicated in Tatton-Brown-Rahman syndrome; hematologic cancer (multiple); and stomach cancer. Orthologous to human DNMT3A (DNA methyltransferase 3 alpha). PHENOTYPE: Homozygotes for a targeted null mutation become runted and die around four weeks of age. Homozygosity for mutations affecting unmethylated histone binding results in abnormal maternal imprinting and abnormal pregnancy. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
