| Primary Identifier | MGI:1920121 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 382562 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable actin monomer binding activity. Involved in acrosome assembly; manchette assembly; and sperm flagellum assembly. Predicted to be located in cytoplasm. Predicted to be active in cell cortex. Is expressed in brain; ileum; and male reproductive gland or organ. Orthologous to human PFN4 (profilin family member 4). PHENOTYPE: Nullizygous mutations of this gene cause male infertility, reduced sperm viability, sperm head shape and flagellar defects, asthenozoospermia and impaired spermiogenesis associated with defects in cis- and trans-Golgi networks, acrosome biogenesis, autophagy, manchette development and mitochondrial structure. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
