Primary Identifier | MGI:2653368 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 194655 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription factor activity. Involved in negative regulation of DNA-templated transcription. Predicted to be located in cytosol; focal adhesion; and nuclear body. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; liver; and sensory organ. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 7 and type 2 diabetes mellitus. Orthologous to human KLF11 (KLF transcription factor 11). PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile, show normal hematopoiesis, growth and development, and display no evidence of increased tumor formation following gamma-irradiation. [provided by MGI curators] |