Primary Identifier | MGI:1346118 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 24057 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable phosphatase binding activity and phosphatidylinositol binding activity. Acts upstream of or within phosphatidylinositol biosynthetic process and regulation of ruffle assembly. Predicted to be active in ruffle membrane. Orthologous to human SH3YL1 (SH3 and SYLF domain containing 1). PHENOTYPE: Homozygous knockout suppresses inflammatory reactions and reduces susceptibility to LPS-induced acute kidney disease. [provided by MGI curators] |