| Primary Identifier | MGI:1913292 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 66042 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable BMP binding activity and BMP receptor activity. Acts upstream of or within several processes, including morphogenesis of an epithelium; negative regulation of signal transduction; and odontogenesis of dentin-containing tooth. Located in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Orthologous to human SOSTDC1 (sclerostin domain containing 1). PHENOTYPE: Mutations in this gene cause variable defects in many aspects of tooth development, including tooth number, size and cusp pattern. Observed phenotypes may include cranial and palatal defects, neonatal death, altered trigeminal ganglion morphology, and resistance to cisplatin-induced renal injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
