Primary Identifier | MGI:1347464 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 15228 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables sequence-specific DNA binding activity. Acts upstream of or within several processes, including neuron differentiation; positive regulation of neuroblast proliferation; and regulation of neuron differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; early embryo; embryo ectoderm; gonad; and sensory organ. Used to study Rett syndrome. Orthologous to human FOXG1 (forkhead box G1). PHENOTYPE: Homozygous mutants exhibit dramatically reduced cerebral hemispheres, missing ventral telencephalic structures, impaired migration of efferent thalamocortical axons, and multiple eye defects. Mutants die at birth from respiratory failure. [provided by MGI curators] |