Primary Identifier | MGI:3647985 | Organism | mouse, laboratory |
Chromosome | 12 | NCBI Gene Number | 238217 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) A structural constituent of ribosome. Involved in male meiosis I; ribosomal large subunit assembly; and spermatogenesis. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in spermatogenic failure 63. Orthologous to human RPL10L (ribosomal protein L10 like). PHENOTYPE: Mice homozygous for a null allele exhibit male infertility associated with testicular hypoplasia, azoospermia,, arrest of male meiosis, male germ cell apoptosis, and impaired ribosome biogenesis in late prophase of meiosis I. [provided by MGI curators] |