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Protein Coding Gene : Akap5 A kinase anchor protein 5
Primary Identifier  MGI:2685104 Organism  mouse, laboratory
Chromosome  12 NCBI Gene Number  238276
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables adenylate cyclase binding activity and molecular adaptor activity. Involved in several processes, including neuronal ion channel clustering; postsynaptic neurotransmitter receptor cycle; and synapse assembly. Acts upstream of or within several processes, including amylase secretion; cellular response to calcium ion; and cellular response to xenobiotic stimulus. Located in cytoskeleton; dendrite; and plasma membrane. Is active in postsynaptic recycling endosome. Is expressed in brain. Orthologous to human AKAP5 (A-kinase anchoring protein 5).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced long term potentiation, improved glucose handling and heightened insulin sensitivity. [provided by MGI curators]
  • synonyms:
  • gene model 258, (NCBI),
  • RIKEN cDNA 3526401B18 gene,
  • BB098886,
  • A kinase anchor protein 5,
  • Gm258,
  • MGI:1918024,
  • LOC238276,
  • MGI:2145066,
  • Akap5,
  • 3526401B18Rik,
  • AKAP150,
  • expressed sequence BB098886
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Genome

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1 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

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Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

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Interactions

5 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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