| Primary Identifier | MGI:2442326 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 268564 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein homodimerization activity. Involved in positive regulation of T cell mediated immunity; positive regulation of lymphocyte differentiation; and thymus development. Acts upstream of or within B cell differentiation and T cell differentiation in thymus. Predicted to be located in nuclear body and nuclear membrane. Predicted to be active in nucleoplasm. Is expressed in several structures, including central nervous system; female reproductive system; jaw bone; submandibular gland primordium; and urinary system. Orthologous to human ZBTB1 (zinc finger and BTB domain containing 1). PHENOTYPE: Mice homozygous for an ENU induced mutation exhibit abnormal thymus, B cell, and T cell differentiation, and reduced numbers of T, B, and NK cells in the spleen. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
